I've done a lot of research on both of those and you can take as much melatonin as you want. Although only three mg should put you out, you can take 3000 with no side effects
As for B6: I'm not sure. Some places say that 2g a day is risky and then other places say that 2g a month is risky. Sites I've been to recommend 25mg-500mg a day... although after looking into it a bit more, I concluded that 150mg a day is moderately safe... although I only take 100.
I hope that helps
~Lance



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