Thread: Bloody Knife-fights

In short - it means that your body is probably experiencing some kind of decay and blood restriction, due to the fact you are using drugs. I'm ignoring all the rest of the stuff - you probably associate knives with blood or something, or power in sex, etc...

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Choline supplementation, huh?

I assume you are hoping that it is going to have some action on your parasympathetic nervous system (PSNS), because you read that it is gonna help produce Acetylcholine through Choline acetyltransferase, and so make you smart(er).

Let us explore a few facts about Choline supplementation, and support our facts with published medical articles - let's pretend we're scientists, instead of trying to drug ourselves into "cool dreams".


1. Nicotine has the a more pronounced effect on the levels of the chemical you are trying to produce, but if you smoke while - trying to - introduce higher levels of Choline into your system, you are going to harm yourself:
Neuropsychopharmacology - Effects of Prenatal Nicotine Exposure on Primate Brain Development and Attempted Amelioration with Supplemental Choline or Vitamin C: Neurotransmitter Receptors, Cell Signaling and Cell Development Biomarkers in Fetal Brain

2. It has been contested that "remote" choline intake (not from food), due to its structure, cannot cross the blood/brain barrier, and so is therefore - probably ineffective.
https://www.ncbi.nlm.nih.gov/pmc/art...316/figure/f5/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/

3. Its action as a Nootropic drug is not accepted even by people I know who are well versed in Nootropics, and it has proven to have no cognitive nor physiological effects in several physical studies:
Choline ingestion does not modify physical or cognitive performance. - PubMed - NCBI
Effect of choline supplementation on fatigue in trained cyclists. - PubMed - NCBI

4. Supplementation with (if it even does what you think it does) / elevated levels of Choline, through Choline acetyltransferase can result in a lack of Homocysteine action in your body. When your cells have Cysteine, they are able to manufacture Glutathione. Low levels of Glutathione may reduce your ability to prevent free radical damage to your cells and may result in impaired function of your immune system.
Cysteine - the Most Important Building Block for Cellular Glutathione Production scn: "why is cysteine important?"

5. With lower (or higher) levels of Cysteine, you are putting yourself at risk of Homocysteinemia, which can make a person more prone to endothelial cell damage, which leads to inflammed blood vessels, which may lead to atherogenesis, which can lead to ischemic injury (damage to tissue due to bloodflow restriction) and can - speculatively - even lead to DNA damage, synaptic dysfunction and cell death.
Medscape: Medscape Access
MTHFR and the Folate Cycle
https://metabolichealing.com/what-is...r-your-health/


6. If, say, the Choline supplementation was increasing levels of the neurotransmitter related to memory and visuospatial perception, - you are using a chemical salt or synthetic version. Let's examine the evidence that the by-product of artificially increased levels of Homocysteine action can do for your neuropsychiatric health (short story, it's not good...):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321271/

Oxidative stress... now where were we just looking at how Choline supplementation might prevent free radical damage..? Ah yes - point 4.

7. The only cognitive effects proven in scientific studies, whereby increased levels of (dietry acquired) Choline have had any positive effect on IQ, memory or visuospatial awareness, is if you are a fetus of a pregnant monkey. You will see that no trials have been run in humans, and the section there is noted to be purely speculative.
Choline concentrations in human maternal and cord blood and intelligence at 5 y of age

8. If you do wish to increase your Choline levels, there are plenty of foods that contain it in a readily useable form, that isn't a synthetic salt. Here are a few of the highest rankers, in order of how much is present:
Beef, Cauliflower, Eggs, Broccoli, Spinach, Wheat germ, Soy, Milk, Tofu, Chicken, Kidney Beans, Grapefruit, Peanuts, Almonds and Brown Rice.

With all those tasty recipes just waiting to be cooked - why are you trying to fake PSNS stimulation through the use of a substance that may or may not leave you stinking of fish..?
https://www.ncbi.nlm.nih.gov/pubmed/11259343

I bet the supplement salt you are taking stinks pretty bad, doesn't it?

I hope you've stopped using it, because your dream is probably your body's way of saying.

Holy fuck boys... Something is happening here - no wonder there's so much blood, I NEED BLOOD BECAUSE OF WHAT THIS GUY HAS SAID IN 8 EASY TO UNDERSTAND POINTS, ALL NICELY REFERENCED LIKE A REAL SCIENTIST AND NOT SOME "ALTERNATIVE MEDICINE" HIPPIE WHO DROPPED OUT OF COLLEGE AND LEARNED HOW MOTHER NATURE CAN HEAL US, BECAUSE COLLEGE IS FOR CONFORMIST DRONES, MAN... (they do teach natural medicine as part of any good pharmacology degree, you know - There's always some truth in hippie medicine, but - like chinese medicine, it usually comes with a great deal of bad ideas and things that "traditionally" cause more harm than good - if not for the human, then probably the gorilla who's testicles you are putting in with your seahorse spunk and rhino horn).


I'd say the bloodthirsty dream was as a result of your supplementation with Choline.
When I first read it, I was going to say, "doesn't matter - you're probably on drugs", and this is kind of the same thing...

I'm all for proven Nootropics, but how can you attest 100% that your experiences are truly yours if you are using synthetic substances to promote these experiences..?

I just did you a lot of hard work, there sucker.
You put anything in your body like that - it never ever leaves - it just diminishes forever.

Oh I forgot your song - two mins....
Here you go:
https://www.youtube.com/watch?v=coHCMdsARuA