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neuro, depends on the particular strain, and one's unique body chemistry.
i'd take around a gram your first time, just in case you are one of those extremely rare people who have severe adverse reactions physically (or psychologically for that matter...though if you've tried other psychedelics, this shouldn't be an issue)
then go to two grams the next experience, then three if neccessary.
as an experienced explorer of the psilocybin multi-verse, 1.5 grams of psilocybe cubensis gives me a fluid mode of thinking, and increased continuity of awareness.
3 grams makes hiking or people watching or music amazing. perhaps slight distortions with eyes open. elaborate close-eye-visuals.
4.5+ grams facilitates a full blown experience, possibly with ego-death and open eye hallucinations.
in a darkened, silent room, your imagination is the only limiter.
(oh, these are dried weights incidentally. fresh mushrooms would be higher dosages to account for the water in them)
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Just like with ecstasy, LSD can drain your brain of serotonin. That can cause depression beyond comprehension soon after the trip wears off. The cure for that is to take a synthetic serotonin antidepressant, like Prozac (must be prescribed), after the depression sets in and the trip has been over for at least a day. I want to start with that warning because I came pretty close to jumping off the Jetty East in Destin, Florida about a week after doing LSD when I was a teenager.
With that precaution stated, I have done LSD twice, and those are about the two most fun times I have ever had. The first time, I took it with two friends. The three of us rode around in a caravan of cars of people who were not tripping but were drunk. For a while, the three trippers were not even in the same cars. We were spread out among the drunks. That was fun, but the real fun started when the drunks passed out and weren't with us any more. We rode around just after sunrise and said off the wall stuff to people out jogging and going for walks. The most interesting effect of LSD and mushrooms for me is how it makes reality seem completely absurd. Everything is meaningless and very comical in a really strange way. In this state, all human behavior is absurd, automatically. Thoughts are incoherent, delusions are formed, and everything is outrageously hilarious. I had this very magnified state of perception of the limits of human awareness and how people get up, go to work, have home and social lives, have some religious views, and go about their days like robots who understand close to nothing. It was beautiful. So asking pedestrians really bizarre questions and watching their responses is almost enough to make me puncture a lung. On top of that, my friend's roof had waves as though it were a body of water. Our conversations made almost no sense, and things would happen like stopping a stop watch to answer a question that has nothing to do with time. It seems really funny in that state. At the end of it, we went to Shoney's to get breakfast. We could not keep straight faces the entire time we were in there, and we were not even sure what was so funny. Somewhere in the trip, my friend and I looked at a vinyl album foldout and decided that two of the members of the band knew the secret of the universe. We really were completely convinced of it. It was awesome.
The second trip was a lot like that, except I was with about seven people who were all tripping, and we were also really drunk. We were almost in a head on collision, and we thought it was one of the funniest things we had ever seen. I definitely don't recommend combining those drugs if you plan on leaving the house. You will be on full blast, out of control, and very lost, all at the same time. Dangerous plan. Outside of that, it was a lot like the first trip. Before I started drinking, I was having anxiety and feeling a terrible edge. I started getting really paranoid in a spiritual/metaphysical kind of way. I felt like we were in the midst of Armaegeddon. The one thing that seemed to be the center of the beauty and peace in the universe was the Joni Mitchell tape we were listening to. Her music had something like a religious nature to it. Then I got to the drinking and lost the paranoia, but ironically gained the danger. I have not done LSD since then. However, if I could find some in this age of ecstasy in which LSD has gone completely out of style in Mississippi, I would like to do some again.