Huperzine A + nicotine + ?
I have bought some Hup A and some nicotine "pills" that you suck on. I will take them wbtb. Is there any other supplement I should use to get the best probability of getting lucid? I want the highest chance since I don't want to use this combination to often.
Should I add melatonine? (Got that aswell). Choline?
Making transdermal huperzine A
Started making my first batch of transdermal huperzine A (H). Crushed a single 200 microgram H tablet and mixed it with 3 teaspoons of ethanol (i.e., Everclear) in a small glass. (Did an online search to make sure H is soluble in ethanol.) Now waiting for the insoluble components of the H tablet to settle out, so I can siphon off the H dissolved in ethanol. Then will mix in some aloe vera and let the ethanol evaporate. (The purpose of the aloe vera is to increase the permeability of the skin, making it easier for the H to pass through it and enter the bloodstream.)
Propylene glycol for use in transdermal supplements
On another thread in this forum, sivason posted the following regarding transdermal supplements:
Quote:
Here is an article that goes into great detail on various formulations they used, and decided the principle is sound,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374332/
This one gets you up to date on transdermal advances for this kind of med.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497436/
The short version seems to be, yes it will absorb through skin. The results seem good and a steady slow release can be achieved. The optimum formulation so far delivers 80% of the medication over 24 hours. So, if the gel contained 10 mg then 8 mg would be spread out over 24 hours, or roughly 2.6 mg over 8 hours. That is the best formulation so far. Anything you do at home is likely to be less.
In general, most simple gels will only get 10% of the drug into your blood over 8 hours, but the characteristics of the drug change that. It sounds like galantamine absorbs pretty well. My best guess is to assume 20% of your drug might be absorbed the way you are doing it. For starters I would use twice the dose you would take orally, and see how that goes. You probably need to wash the area with alcohol in the morning so you are not absorbing it all day too. Going up in strength until you get the dose you want based on results, you will likely end up finding out that almost 20 mg will be needed, but do not jump to that high of a level before trying 8 mg.
Disclaimer: This info is for theoretical educational purpose only. I do not encourage anyone to rely on my opinion when ingesting chemicals. Do so at your own risk. Good luck. If the raw chemical is not too expensive it could be a good project. Note: there are dangers involved with galantamine as with any real serious medication. I have never used it and in general think strong drugs like this are best to be avoided.
I've read the first paper mentioned in that post: Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System, by Woo Fong Yen et al. Looks like the authors found that propylene glycol works well with galantamine as a skin-permeation enhancer:
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3.1.5. Effects of Enhancer Amount on Drug Release. Propylene glycol showed the highest drug release when compared to other penetration enhancers. Figure 5 and Table 2 show the effects of propylene glycol amount (0.00%, 1.00%, 5.00%, and 10.00% w/w) on drug release. There was no significant improvement on drug permeability when the amount of propylene glycol was increased from 0.00% to 1.00% w/w. However, an improvement in drug release percentage was observed when percentage of propylene glycol was increased from 5.00% to 10.00% w/w. The highest drug release percentage was observed with gel which consisted of 10.00% w/w propylene glycol. Santos et al. and Trottet et al. also deduced that propylene glycol content in the formulations is directly proportional to the amount of drug permeated and drug release [19, 20].
It might also work well for transdermal Huperzine A. Just ordered some propylene glycol, so I can do some tests.
Re: Propylene glycol for use in transdermal supplements
Quote:
Originally Posted by
Zthread
It might also work well for transdermal Huperzine A. Just ordered some propylene glycol, so I can do some tests.
The propylene glycol I ordered arrived yesterday. Going to try using it to make some transdermal supplements, starting with transdermal galantamine.