Originally Posted by
tommo
Ah, ok, I thought that may have been what you meant....
Nope, I was actually looking a while ago for Ketamine analogues, but I didn't find much IIRC. Except for PCP, but.... nope nope nope.
Why are you interested in the kappa opioid action?
It seems to me the NMDA antagonism is what causes it's unbelievable effects. Coincidentally (since you were talking about headaches)
I was reading John Lilly's book on floatation tanks and he said he once used it in combination with Ketamine IM, and he basically visualised
his migraines as a ball of energy or something and he pushed it out of his head, and the migraine was gone, but it kept coming back in.
He told his assistant to give more injections and eventually after 3 doses I think, the ball got infinitely far away and vanished from sight,
and he never got another migraine again. He thought he'd have to re-dose eventually, but he never did.
I've read some insane things like that about Ketamine, and IIRC it is hypothesised that it's NMDA activity is somehow responsible for
it's almost brain-resetting effects - cure addiction, depression, anxiety, OCD, intense chronic pain etc.