I recently started taking B6, and was reading through the tutorial, and read the following in particular:

"Adverse Reactions:

The most common adverse reactions to vitamin B6 are centered in the nervous system. Peripheral neuropathy, with loss of sensation in the hands and feet, may occur, along with permanent nerve damage. Ataxia, somnolence, and disturbance of gait are also seen. The likelihood of these adverse effects is increased by high doses similar to the commonly used 200 mg/day."
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I was curious if anyone knew the actual likely-hood of such cases appearing..??