My bottle of B6 tablets contains 50 milligrams per tablet. It recommends you take one of these per day. This is listed as 2500% of the USRDA. Two of those (I.E. 100 milligrams) would then be 5000% of the USRDA. That's 50 times the USRDA. Also evidenced by the fact that the "high-end" of the USRDA is 2 milligrams/day. 100 milligrams is 50 times that.
Now, more to the point: When I said "a whole freaking lot" I meant in excess of 500 milligrams a day. I suppose it was my fault for not directly specifying. According to
Merck (a manufacturer of pharmaceuticals) the required dose for toxicity is 2 - 6 grams over a period of 2 - 40 months.
But
this is from the National Institute of Health:
What is the health risk of too much vitamin B6?
Too much vitamin B6 can result in nerve damage to the arms and legs. This neuropathy is usually related to high intake of vitamin B6 from supplements, [28] and is reversible when supplementation is stopped. According to the Institute of Medicine, "Several reports show sensory neuropathy at doses lower than 500 mg per day" [12]. As previously mentioned, the Food and Nutrition Board of the Institute of Medicine has established an upper tolerable intake level (UL) for vitamin B6 of 100 mg per day for all adults [12]. "As intake increases above the UL, the risk of adverse effects increases [12].
That's what the government had to say about it. Either way I maintain that it is unwise to start with a large dose when dealing with a supplement you've never taken before. I guess in the end my point was you can get too much of just about anything. (I.E. Water Toxicity) I believe in the value of informed decisions with as much information as possible. So that's where I was coming from.
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