I got a gram of Calea Zacatechichi yesterday and tried it out with my Da Buddha vaporizer last night. I did research on erowid.org and other online resources and felt comfortable that it was safe.
1st Trip Report:
I am glad I am doing this in a vaporizer and not drinking or smoking it, it does have a bitter flavor. The vaporizer aftertaste is little bitter, but a hint of mint. Not bad. After four hits I felt a bit dopey and my equilibrium was a bit off. A slight high. I felt tired, but at the same time had a mental clarity. It's like half of my brain is turning off to go to sleep, while the other half is still on. I can really see how this herb can lend itself to lucid dreaming. I fell asleep after 20 minutes (fast for me). No lucids. I was not expecting anything with the first dosage as most of the experiences on Calea Zacatechichi require a least three nights of use before experiencing any effect. Woke up the next morning feeling normal.

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