
Originally Posted by
Pan
Well there's really no simple answer here. Sleep paralysis/REM atonia is the result of inhibition of motorneurons, which is a process that scientists are still trying to understand better. It is generally accepted that sleep paralysis is caused by the release of glycine, an amino acid, from the brain stem onto the motorneurons. Some neurotransmitters and hormones are known to generate the many components of REM sleep, but there's no specific hormones that directly cause sleep paralysis. Examples: acetylcholine seems to be responsible for REM, but not Sleep Paralysis. Carbachol, a cholinergic agonist, and also melatonin have important roles in enhancing the REM state. Such neurotransmitters and hormones probably activate or inhibit the activity of second messengers, which then activate or inhibit the third messengers, and so on till the last messenger inhibits the synaptic transmission or causes hyperpolarization of the motorneurons. When the nervous or endocrine system continues to release the neural inhibitors, a person may experience Sleep Paralysis as he enters awakefully into or awakens directly from REM period.
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