Hi all,

I was wondering if there are any long term consequences for using Galantamine and Choline about once a week...then I reviewed Yushak's book a bit more closely and came to the answer on my own. I am posting it here for anybody else who may be concerned as I was. Obviously, a healthy dose of caution is still advised for any supplement...but the author did address this issue. I did do some due diligence to see if this question was already posed, but I would be lying if I said I checked every single thread/group.

Basically: Even without Piracetam to 'reset' acetylcholine levels sooner, the brain will adjust and regain normal sensitivity if you use correct dosing and wait long enough...4 days based on Galantamine's 48 hour timing and Choline's 12 hour timing.

In Thomas Yuschak's Advanced Lucid Dreaming: The Power of Supplements Chapter 18, he talks about how desensitization from boosted acetylcholine receptors can can cause acetylcholine receptors to lose sensitivity. He also covers long term and short term desensitization:

Desensitization, on the other hand, must be avoided.
Desensitization is a physiological event. Galantamine causes
increased levels of acetylcholine to be present in the brain for up to
48 hours after you take a dose. This increased concentration can
literally cause the receptors that the acetylcholine binds with to start
to lose their sensitivity. This means that in order to have the same
physiological effect you will need to increase the acetylcholine levels
even further (i.e. take a larger dose of Galantamine) in order to get
the same effect as you had with the initial doses. The larger dose
causes further desensitization and hence a vicious cycle continues
until one reaches a high enough dose that negative side effects begin
to surface. Fortunately clinical studies show that Galantamine does
not cause long term desensitization. Short term desensitization can
be countered by letting the level of acetylcholine within the brain
return to its normal state for some period of time before taking
another dose.

Happy dreaming ya'll.