
Originally Posted by
O'nus
5-HTP is serotonin. What do you mean serotonin suppresses REM sleep..? Where are you getting this from..?
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Just to follow up a bit on this. I did a search on Google, and I found this article: "Biogenic Amines and the States of Sleep", Michel Jouvet, Science 163 (862) pages : 32-41 (1969). A couple of relevant quotes from the article (my emphasis):
"In birds, whose blood brain barrier is permeable, intravenous injection of serotonin or noradrenalin leads to slow-wave sleep, as indicated by hehavior and by electroencephalographic recording (25)."
"The increase of cerebral serotonin (through intravenous or intraperitoneal injection of its precursor 5-hydroxytryptophan (5 HTP)) leads first to a state which resembles slow-wave sleep (28). However, this drug leads to a suppression of paradoxical sleep for 5 to 6 hours; the suppression is followed by a secondary rebound (29)"
Note that "paradoxical sleep" is better known today as REM sleep.
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