I didn't read everything but I would think the main difference between science/mathematics and spirituality/religion is that I'm able to create something physical out of science/mathematics. I can feel it, I can see it, I can use it without knowing anything complicated. Whereas spirituality/religion is ideas, ideas and more ideas. You get nothing physical out of it and it can change with a thought. That's why more people prefer to trust science/mathematics.

I think I didn't answer your post, I merely answered your title. A typical example of tl;dr.