This question posed an interesting challenge for me, as my morals are based on a kind of generous pragmatism--essentially I act selfishly but with a very broad notion of self-interest, understanding that what's good for the world is good for me, and what's bad for the world is bad for me. The concept of "wickedness" or the worst possible act is a little foreign to that framework, but here's what I came up with:

1. Suffering. I might have said inflicting suffering, but it's not possible to do so; one suffers or not. I'm not sure I can convey this clearly, but I'm not saying that it's "our fault" when we suffer due to death, injury, violation or betrayal, but only that one must have been suffering beforehand in order for that suffering to be exacerbated by events. What's more, all "wicked" acts have their roots in the perpetrator's habits of suffering, so whether murder, rape, theft, or betrayal, all begin with suffering.

I think it's clear how 2 & 3 don't apply in this case; one can't suffer to ease suffering, one can only free oneself from suffering.