I sorta agree with human.
The ego is something like a mask which covers your true connection with the surrounds, your true self. But if we were to stay true, we would probably all become ascetics and stuff, searching for that religious xpereience, leaving aside the other aspects of our life, equally important each one of them.
The bliss of dissolving the ego, and then rebuilding it in a better fashion is an experience one should do, in important moments of their life. Not just intending to trip, or to have fun. Its, like human said, a sacrament, a re-union with the (w)holy part of our life.

And i didnt talked about teonanacatl (the sacred name for mushrooms in ancient mexico, which means gods' flesh) because i think their revelations are even more complex than the acid ones, as they have a living essence, unlike the acid, thus, i dont feel ready for that type of communion