Alright so Firefox crashed on me mid-way through my reply to Ne-yo. I don't particularly care to reply to his entire post, as I will only end up repeating myself for the fifth-or-so time, but there is one glaring issue that needs to be discussed. The issue is Ne-yo's use of anti-abiogenesis sources.
Of course, they aren't really anti-abiogenesis sources at all (except for one). As we shall see, Ne-yo clearly did not read the papers he linked at all. Or if he did, he misinterpreted what they were saying.
Source 1: Dr. Herbert Yockey, cited here.
There are a few problems with the use of this source. The first is that the article is on freerepublic.com, a conservative propaganda machine connected to Ann Coulter and people of that ilk. Does this really have anything to do with Ne-yo's use of the article? Not really, but it gives us reason to be skeptical about the information contained in the article. The second problem is that the article is titled "Evolution is Biologically Impossible," which again gives us reason to be skeptical. The third problem is that the article was written by one Joseph Mastropaolo, PhD, from the Institute for Creation Research of all places. Again, another reason to be skeptical. Anyway, this is just peripheral stuff.
The link to the article Ne-yo presented has been provided above. This is the relevant section Ne-yo quoted on page 15 of this thread:To set a better example, let us take up the evolutionist's burden of evidence to see where it leads. Our first observation is that apparently all functions in a living organism are based largely upon the structures of its proteins. The trail of the first cell therefore leads us to the microbiological geometry of amino acids and a search for the probability of creating a protein by mindless chance as specified by evolution. Hubert Yockey published a monograph on the microbiology, information theory, and mathematics necessary to accomplish that feat. Accordingly, the probability of evolving one molecule of iso-1-cytochrome c, a small protein common in plants and animals, is an astounding one chance in 2.3 times ten billion vigintillion. The magnitude of this impossibility may be appreciated by realizing that ten billion vigintillion is one followed by 75 zeros. Or to put it in evolutionary terms, if a random mutation is provided every second from the alleged birth of the universe, then to date that protein molecule would be only 43% of the way to completion. Yockey concluded, "The origin of life by chance in a primeval soup is impossible in probability in the same way that a perpetual motion machine is impossible in probability."7 Well, for one, Yockey isn't a biologist, he's a physicist, and a noted critic of the primordial soup hypothesis due to his application of information theory to biology. Normally this wouldn't be a problem, but shouldn't we be looking for sources by biologists who actually work in the field(s) concerning the origins of life? That is not to say Yockey is wrong simply because he isn't a biologist, but unfortunately, I don't think we'll know. Why? I don't have the book Yockey wrote, which was cited in the article by Mastropaolo (Information Theory and Molecular Biology), and I can't find it online. Unfortunately, I can't say much more than that. Well, I can say that Ne-yo should be more careful with his source citations. His case would've been stronger had he linked us to Yockey's book and not an anti-evolution article by a creationist.
Source 2: Francis Crick, cited here.
This source is from a noted biologist and origin of life researcher famous for discovering the structure of DNA, so its odd that Ne-yo would use it in his favor. Also, I can't find the statement Ne-yo quoted in the source, pasted below:An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. So either I suck at finding it, or it isn't in the source. But let's have a little fun with it anyway.
Well, to be blunt, the quoted section doesn't really help Ne-yo's case. Crick states that given the information available to scientists at the time he wrote those words, the origin of life may have been considered a miracle since a lot of conditions had to be just right in order for life to be started. However he does not say that abiogenesis is impossible, which is what Ne-yo said when replying to Mario:The probability is so extremely low that mathematicians deem an event of this nature would be impossible given the inverse of the upper limit of the total number of (possible) specified events throughout cosmic history. So in short you just explained me that you put your stock into an impossibility. Mario asked to see the mathematicians, and Ne-yo listed Crick among them. Why? I have no idea since Crick isn't a mathematician, and it doesn't really help his case anyway because like I said, Crick didn't say abiogenesis is akin to a miracle because its impossible. Rather, he said that based on information at the time, abiogenesis may seem like a miracle since various conditions had to be satisfied for it work. There is indeed a difference between the two.
In addition, in this piece, Crick and Leslie Orgel state that they did not anticipate various discoveries since the publication of their papers concerning molecular replication and the evolution of protein synthesis. They explicitly state that they would now have an open mind concerning discoveries that show RNA may not have been the first replicator system. Basically they're saying they may have been a little pessimistic.
And what a wonderful segue to our last source.
Source 3: Leslie Orgel, cited here.
Orgel is another biologist noted for his work in origin of life research. So again, it's odd Ne-yo would use him as a source against abiogenesis. Anyway, Ne-yo cites this section of Orgel's paper:The explanation of this is simple: noncovalent interactions between small molecules in aqueous solution are generally too weak to permit large and regiospecific catalytic accelerations. To postulate one fortuitously catalyzed reaction, perhaps catalyzed by a metal ion, might be reasonable, but to postulate a suite of them is to appeal to magic. An appeal to magic? Surely You're Joking, Mr. Orgel! A picture needs to be painted. What is Orgel talking about, exactly?
From the abstract of the cited paper:I examine the plausibility of theories that postulate the development of complex chemical organization without requiring the replication of genetic polymers such as RNA. One conclusion is that theories that involve the organization of complex, small-molecule metabolic cycles such as the reductive citric acid cycle on mineral surfaces make unreasonable assumptions about the catalytic properties of minerals and the ability of minerals to organize sequences of disparate reactions. Another conclusion is that data in the Beilstein Handbook of Organic Chemistry that have been claimed to support the hypothesis that the reductive citric acid cycle originated as a self-organized cycle can more plausibly be interpreted in a different way. Well that certainly doesn't look like Orgel is saying "abiogenesis is impossible," does it? That's because he isn't. In the first sentence alone, Orgel states that he will examine "the development of complex chemical organization without requiring the replication of genetic polymers such as RNA." So it seems he's discussing the mechanisms by which abiogenesis, or life from non-life, worked. This point is supported further when we look at what Ne-yo quoted, in full:The formose reaction does not proceed at an appreciable rate under neutral conditions, and even at high pH, is inefficient in the absence of a catalyst such as a divalent metal ion, for example Ca2+ or Pb2+ ( 23). My first observation then is that each step of a proposed cycle must proceed at a reasonable rate, and that this will often depend on the availability of a suitable catalyst. If one of the component reactions of a proposed cycle does not proceed spontaneously or under the influence of a plausibly prebiotic catalyst, some additional hypothesis will be needed to maintain the relevance of the cycle to the origins of life. If several of the reactions need “help,” desperate measures will be called for.
One possible saving hypothesis is that the molecules that are the carriers of the cycle are also catalysts for the difficult reactions of the cycle. Unfortunately, catalytic reactions of the required kind in aqueous solution are virtually unknown; there is no reason to believe, for example, that any intermediate of the citric acid cycle would specifically catalyze any reaction of the citric acid cycle. The explanation of this is simple: noncovalent interactions between small molecules in aqueous solution are generally too weak to permit large and regiospecific catalytic accelerations. To postulate one fortuitously catalyzed reaction, perhaps catalyzed by a metal ion, might be reasonable, but to postulate a suite of them is to appeal to magic.
Hmm, nothing about abiogenesis being impossible there. Sounds like Orgel is doing exactly what he said he would in the abstract, namely critiquing hypotheses surrounding the plausibility of the development of complex chemical organization without RNA.
Of course, we can point to the retrospective article I linked to while discussing Francis Crick for information on Orgel's more recent thoughts on complex chemical organization without RNA.
But wait, what about the conclusion to the Orgel paper?The novel, potentially replicating polymers that have been described up to now, like the nucleic acids, are formed by joining together relatively complex monomeric units. It is hard to see how any could have accumulated on the early earth. A plausible scenario for the origin of life must, therefore, await the discovery of a genetic polymer simpler than RNA and an efficient, potentially prebiotic, synthetic route to the component monomers. The suggestion that relatively pure, complex organic molecules might be made available in large amounts via a self-organizing, autocatalytic cycle might, in principle, help to explain the origin of the component monomers. I have emphasized the implausibility of the suggestion that complicated cycles could self-organize, and the importance of learning more about the potential of surfaces to help organize simpler cycles. Don't the underlined sections show that Orgel thinks abiogenesis is impossible? What ever will we do? Well, we'll look at everything else Orgel said, highlighted in bold. Looks like he's still talking about the plausibility of mechanisms for abiogenesis rather than the plausibility of abiogenesis itself. And of course this is completely in line with everything I've stated in this thread. Life had to have come from non-life, but the mechanism hasn't been identified, and work is being done in that area.
In summary, read your sources, make sure they support your case, and try not to use creationist sources. If we're going to have a proper scientific discussion, let's use scientific sources and not mythological babble.
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