This seems like a pretty good idea for those who aren't too sensitive to it. I'll unfortunately be sitting this one out for that reason, but I'm interested to see the results!

Quote Originally Posted by Xanous View Post
Also I wonder if REM suppressants like 5HTP or a high dose of melatonin would be beneficial. What do you guys think? Would that be adding too much to the mix?
I assume you mean taking them when you originally go to bed? That could be interesting....

I've done some research on REM rebound and they found a link between it and cannabinoid CB1 receptors in the hippocampus. Those receptors are also known to induce REM at only certain times of the day, with the best time for it presumably being still technically during the night but after a few REM cycles have already passed (in other words, a WBTB?), and they have hallucinogenic effects which likely play an important role in the generation of dreams. Adenosine A1 receptors, which caffeine inhibits, directly oppose the effects of hippocampal CB1 receptors. That means that caffeine should allow endocannabinoids to produce their dream-related effects more strongly when taking at the right time. This is of course in addition to increase the release of acetylcholine, which induces the synthesis and release of endocannabinoids there. So I would be willing to bet that effectively combining it with REM rebound could produce some nice results.