Originally Posted by dutchraptor
@Aly That is really cool. Would that mean that the half life of menthol in the body doesn't matter that much either and that we could take menthol before sleep?
Well, I've always thought that personally lol. I've only ever taken it before sleep. How much this directly applies to it I'm not sure, but I suppose it's possible. Kappa-opioid receptors are known for having long-lasting effects. I've heard anecdotally that the cAMP depletion it causes doesn't re-balance itself as quickly as the drug effects wear off. I also know that kappa agonists are known to have long-lasting anti-addictive effects. (Maybe even caused by that same cAMP depletion?) And though it's not the exact same, but is the same receptor, I think kappa antagonists are the shining star of long-term effects. Selective ones tested in labs have been shown to have antidepressant effects lasting for weeks after a single dose, effects that are not reversible by using kappa agonists. So clearly they have a lingering effect in the body.
One thing I really wonder about with the anandamide potentiation is the sexual effects.... I didn't include this in the research post because I think it's too theoretical, but I always link the hippocampus to the imagination, and smoking weed makes my imagination become highly sexual. And if dreams, which are also hippocampal in origin, are just the imagination forced to encompass reality, I think it could make sense that increased cannabinoid activity there could account for the same kind of effects in dreams. I also wonder about its implications on the perception of spacetime, but that's a thought for another post....
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