I had no idea either! I've seen its other known receptor properties in multiple places, but this is news to me. It seems to be relatively unknown. I really don't know how to compare it to the other effects either, but I'm guessing that the kappa-opioid effects are stronger than the GABA(A) effects since menthol is known to produce analgesia at doses that really don't provide any sedation. That's just based on experience though and reports though. It's hard to actually say at this point.
Oh, I've been meaning to ask, do you feel any analgesic effects from menthol? I can feel some of the opioid relaxation myself but I also know that female sex hormones cause kappa-opioid receptors to link up with mu-opioid receptors in the spinal cord and as a result women get much more analgesia from kappa agonists than men do on average, so I'm just curious how much of an effect it has for you.
Hahaha, yeah, that eventually got me there.
I actually found some interesting things about TPRM8 too, there was a thing about how it gets deactivated by arachidonic acid formed from phospholipase A2 activation my M3 muscarinic receptors. I'm not sure about from phospholipase C... but it's an interesting thought because it means that the more acetylcholine there is active at the same time as menthol the less TPRM8 activation there will be. I'm not totally sure what that receptor does there in the first place, but it definitely makes me wonder more about the effects of combining menthol and choline!
And I'm glad you like it, I was excited.
I've been reading about Xenopus oocytes for a long time now, so I'm afraid you might be alone in that one.
Nice!
Hey just out of curiosity, how much of an effect do you notice from the fish oil? I've been really interested lately in how it effects anandamide's activity on the endovanilloid system!
About the WILDing, I've actually had two WILDs ever and each were by accident, and the second one (I believe...) was after a night of taking menthol. Highlander reports lots of good hypnagogic stuff with it too. Given its receptor affinities, particularly these new ones, it probably does just make it easier to reach that state.
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