Quote Originally Posted by Alyzarin View Post
Congrats, Canis! Sounds like you had an awesome night! It's interesting that you just decided to try that combination, because I was just thinking about it the other day. You know that thing I said up above about how kappa-opioid receptors increase endocannabinoid synthesis by activating phospholipase C? I later read that muscarinic acetylcholine receptors actually work through this exact same process, and these two also increase the release of inositol trisphosphate and calcium to enhance long-term potentiation (involved in learning and memory), so I was thinking that combining choline and menthol could actually be synergistic in this way. So I'm glad to see this, very interesting results!
Thanks, Aly, I did! To the point where I have to ask myself the question whether I'll make this "a thing" every few weeks...? (As if I wasn't already a big enough menth-head.) So many exciting freakin combinations out there.

I am really liking your thoughts on the possible synergies between the kappa-opioid receptors and the mAChR's. That makes a whole lot of sense. When I get a little time I will need to catch up on some reading in this area! I may have to try some more modest experiments with a little choline bitartrate, for example. Galantamine is such an ACh power tool that I'd like to see what less aggressive, more subtle approaches do.

This is fun!